The purpose of the workstream is to provide guidance to industry, regulators and academic researchers of the age-appropriateness of different pharmaceutical dosage forms for use in children.

These include:

  • The development and evaluation of medicines for marketing authorisations
  • The use of modifications to the dosage form (Extemporaneous Preparations or compounding; manipulation at the point of administration and Industry Verified Preparations and manipulations) in practice

Our current priorities are:

  • Dosage form acceptability, safety, efficacy and dose flexibility
  • Modified release formulations
  • Routes of administration
  • Food/drink effects on administration of medicines
  • Safety and efficacy of co-administration
  • Manufacturing challenges in developing paediatric formulations

Our achievements to date include:

  1. Liu F, Ranmal S, Batchelor HK, Orlu-Gul M, Ernest TB, Thomas IW, Flanagan T, Tuleu C., Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations. Drugs. 2014, 74:1871-8 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210646/pdf/40265_2014_Article_297.pdf
  2. Liu F, Ranmal S, Batchelor HK, Orlu-Gul M, Ernest TB, Thomas IW, Flanagan T, Kendall R, Tuleu C, Formulation factors affecting acceptability of oral medicines in children. Int J Pharm. 2015, 492:341-3. http://ac.els-cdn.com/S0378517315004238/1-s2.0-S0378517315004238- main.pdf?_tid=061a9704-52f1-11e5-8bc4- 00000aacb35e&acdnat=1441363264_c92640c8412f8899bb4630963a3b638b
  3. Presentation at EuPFI annual meeting 2014: Formulation factors affecting acceptability of oral medicines in children and older adults

If you are interested in joining or would like further information please contact Fang Liu (f.liu3@herts.ac.uk) and Terry Ernest (terry.b.ernest@gsk.com)

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