About the conference

Marking the 10th anniversary of the Paediatric Regulation and foundation of the European Paediatric Formulation Initiative (EuPFI) consortium, EuPFI convoked its 9th annual conference with the International Association of Pharmaceutical Technology (APV) on 20th and 21st September 2017 at Biological and Chemical Research Centre, University of Warsaw, Poland. The participation of ~180 delegates from Industry, Academia, Regulatory and other organizations from 26 countries with diverse backgrounds and involvement in both formulation development and regulatory submissions provided a productive setting to reflect back on the past decade of paediatric formulations, to celebrate accomplishments, to welcome new researchers and enrich networking opportunities and to consider how novel and emerging technologies will yield further insights into what the future may bring.

To get ready for next 10 years, join and celebrate our 10th conference next year, 11th to 13th September 2018, in London where we want to be more global, encompassing developing countries and their needs. Watch the space!!!

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie, Mihaela Friciu, V Gaëlle Roullin, Grégoire Leclair. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho; Cathie Berg; Fabiana Banov, PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod, Don Barbieri, SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka, T. Mills, H.K. Batchelor, School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y., Forest, A., Girard, J.M., Deleglise, C., Marchaud, D. Gattefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska; Joanna Krotka; Malgorzata Sznitowska, Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani; Takahiro Kawagishi; Naohisa Wada; Atsushi Yamada; Takahito Kimura, Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins; Trevor Riley; Nadeen Jibry; Debbie Hunt; Jayadevan Jayadevan Thekele;Anya Batalina, GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk, Malgorzata Sznitowska, Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

Optimizing spray congealing parameters and formulation to improve taste masking of bitter drugs
Inês Matos1; Peter Stayer2; João Henriques3 1 Hovione FarmaCiência SA, Loures, Portugal, 2 Budapest University of Technology and Economics, Budapest, Hungary, 3 Hovione FarmaCiência SA, Loures, Portugal

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan1; Jean Baptiste Petit1; Matthew Peak1,2 1 MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Standardize 4 Safety: A U.S. Project Going Global
J Deborah A Pasko, Pharm.D, MHA

Child-driven design of milk micelles for drug delivery
Tânia Fernandes1, João Aguiar1, Sophie Scheppe2, João F. Pinto2, Ana I. Fernandes1, 1 CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, 2 iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Continuous inkjet printing of enalapril maleate onto orodispersible films
Yasmin Thabet, Dina Kottke, Joerg Breitkreutz, Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany

Delayed release orodispersible mini-tablets
Anna Kira Adam1; Jörg Breitkreutz2 1 Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa1; Frank Kloprogge1; Hsiao Wen Kai2; Amrit Paudel2; Massimo Bresciani2; Simon Gaisford1; Mine Orlu1 1 UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK 2 RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
1,4M.Peak, 2J.Madathilethu, 2J.Ford, 1,2R.Prescott, 3J.Blair, 1,2M.Roberts 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF 3 Department of Paediatric Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 4NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
1P.Mistry, 1L.Bracken, 2U.Ohia, 3H.Jones, 3N.Kanji, 4F.Liu, 1M.Peak 1 Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 2 NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP 3 Co-Formulate Ltd, MediCity, Nottingham, NG90 6BH 4 Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, AL10 9AB

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
J. Autmizguine1,2,3; Z. Allakhverdi1,2; A. Gilpin1; J.-E. Tessier1; D. Giroux1; D. Lebel1,4; C. Litalien1,2,3 1 The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada; 2 Department of Pediatrics, CHU Ste-Justine, Université de Montréal, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada 3 Department of Pharmacology, Université de Montréal, 2900 boulevard Édouard-Montpetit, H3T1J4, Montréal, Canada 4 Department of Pharmacy, CHU Ste-Justine, 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo1; Song Sang-Byeong1; Lee Jae-Min1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
1C. Watson, 1E.A. Webb, 2J. Porter, 2A.M. Lewis, 2H. Coope, 3H. Stirling 1H.K. Batchelor 1 School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK 2 Diurnal Ltd, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ 3 Paediatric Department, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Walsgrave, Coventry, CV2 2DX, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington1; Christopher Granelli2; Karen Thompson3 1 Merck & Co., Inc., West Point, PA, USA, 2 Merck & Co., Inc., Rahway, NJ, USA, 3 Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene1,2; Aslak Steinsbekk1 1 Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Lee Jae-Min1; Song Sang-Byeong1; Song Chan-Woo1; Jung Ki-Won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Jung Ki-won1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won1; Song Sang-Byeong1; Lee Jae-Min1; Song Chan-Woo1; Noh In-Hwan1; Rhee Yun-Seok1, 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

AZATHIOPRINE ORAL SUSPENSION -a case-study
Cosme Silva, F1; Marto, J2; Rodrigues, V3; Ferreira, MP4, Almeida, AJ5, 1 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 2 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal, 3 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal, 4 Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal , 5 Research Institute for Medicines (iMedULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

Safe, swallowable and palatable: A novel paediatric mini-tablet formulation for a WHO Model Lists of Essential Medicines for Children compound
Lisa Freerks1; Jana Urbaniak1; Sandra Klein1, 1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov1; Ashley Shan1, Kendice Ip1, Maria Carvalho1, 1 PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
A. Grave1, N. Poellinger1, M. Hug2, 1Glatt GmbH, Pharmaceutical Services Binzen, Germany, 2credentis AG, Windisch, Switzerland, Correspondence to: Glatt Pharmaceutical Services, Werner-Glatt-Str. 1, D-79589 Binzen

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET1; Anne-Marie PENSE-LHERITIER2; Améziane AOUSSAT3; Fabrice RUIZ4, 1 ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France, 2 EBInnov, Ecole de Biologie Industrielle (EBI), Cergy, France, 3 LCPI, Arts et Métiers ParisTech, Paris, France, 4 ClinSearch, Malakoff, France,

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
1S.Keser, 2C.Timpe, 2A.Dischinger, 3B. Hahn 1 Glatt GmbH, D-79589 Binzen 2 F.Hoffmann La Roche AG, Grenzacher Str. 124, CH-4070 Basel 3 Heinrich-Heine-University Duesseldorf, D-40225 Düsseldorf

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer1/2, K. Pápai-Herczeg1, M. Preis3, J. Breitkreutz2, J. Broscheit1/4, N. Roewer1/4 1 Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany 2 Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany, 3 Åbo Akademi University, Artillerigatan 6A, 20520 Åbo, Finland 4 University Hospitals of Würzburg - Anaesthesia and Critical Care, 97080 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu1;Rikhav P Gala2; Gregory T. Knipp3, Robyn R McCain3, Martin J. D’Souza2, Roquette America Inc, 2 Mercer University, 3 Perdue University

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita, J. Breitkreutz, Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitaetsstraße 1, 40225 Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto1; Koji Komori1, Yutaka Okuda2, Hidefumi Nakamura3, Shinji Yamashita1 1 Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan, 2 Towa Pharmaceutical Co., Ltd., 26-7, Ichiban-cho, Kadoma, Osaka, Japan 3 Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit1,Catherine Guittet1, Luc-André Granier1 1 Advicenne, 2 rue Briçonnet, Nîmes, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi1; Andreas Zimmer2; Massimo Bresciani1 1 RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F.1, Kelly, H. 1, Breatnach, C. 2, Howlett, M.2, O’Brien, F1.1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2. 2 Our Lady’s Children’s Hospital Crumlin, Dublin 12

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer1, Lisa Freerks1, Anna-Elena Hetberg1, Frank Karkossa1, Greg Neal2, Martin J. Whitaker2, Daniel Margetson2, John Porter2, Sandra Klein1 Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany, 2 Diurnal Limited, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen1, MSc; S. Buljac2, BSc; Prof. Dr. A.G. Vulto3; Dr. L.M. Hanff3 Department of Hospital Pharmacy, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Extrusion of highly drug-loaded wax-extrudates for paediatric use
Bastian Hahn; Julia Dronov; Natalie Nitschke; Jörg Breitkreutz, Institue of Pharmaceutics and Biopharmaceutics, Heinrich Heine University

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke; J. Breitkreutz, Heinrich-Heine-Universität Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; Universitätsstraße 1, 40225 Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks1; Deirdre M. D’Arcy2; Nigel K. H. Slater3; Lydia N. Drumright1 1 Department of Medicine, University of Cambridge, Cambridge, UK CB20QQ, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland 3 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB30AS

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
1Wei Zhu, 1Melanie Marota, 1Tom Colace, 1Jeff Mora, 2Barbara Davit, 1Dina Zhang and 1Yunhui Wu, 1 Pharmaceutical Sciences and Clinical Supply, 2Translational Pharmacology, Merck & Co., Inc.,

Assessing the sample size necessary for a human taste panel
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX; 3 Supervisor; Third Avenue, New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London, WC1N 1AX

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives, Kamal Lalgi Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley1; Mine Orlu2; Terry Ernest3; Catherine Tuleu4 1 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London, 3 Supervisor; New Frontiers Science Park, Harlow, Essex, CM19 5AW, United Kingdom; 4 Supervisor; 29-39 Brunswick Square, London WC1N 1AX

A Study of the Slipperiness of a Developmental Immediate Release Film Coating System
P. Smith1; J. Gimbel2; D. To2; J. Teckoe1; A. Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK

Understanding the Integrity of Coating for Taste-masked Granules – Before and After Tablet Compression
P Smith1; R Mehata2; C Cunningham2; A Rajabi-Siahboomi2 1 Colorcon Ltd., Dartford, UK 2Colorcon Inc., Harleysville, USA

Crushing of melatonin tablets (Circadin®) for safe and reliable delivery via paediatric nasogastric tubes.
Magda Swedrowska1; Naomi Ko1; Steve Ingham1; Stephen Tomlin2; Ben Forbes1 1 Institute of Pharmaceutical Science, King’s College London, King’s Health Partners, London SE1 9NH, UK; 2 Pharmacy Department, Evelina London Children’s Hospital, Guy’s & St. Thomas’ NHS Foundation Trust, King’s Health Partners, London, UK

Age related biorelevant solubility and dissolution testing and its inclusion in paediatric PBPK modelling for a BCS 1 compound with intestinal metabolism
Brown J2, Mencarelli G1, Jones J2, Timmins, P2, Fotaki N1 1University of Bath, School of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK 2 Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, Wirral, CH46 1QW

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim1; Catherine Tuleu1; Alastair Coupe2 ; Mohan Edirisinghe3; Duncan Craig1 1 School of Pharmacy, University College London, UK 2 Pfizer Ltd, Sandwich, UK 3 Department of Mechanical Engineering, University College London, UK

Workshops Presentations

Workshop 1: Benefit risk approach to dosage form design for paediatrics

Opening Presentation

Wrap up Presentation

Jenny Walsh, Jennywalshconsulting,UK

Workshop 2: How to construct/evaluate Paediatric Investigation Plans (PIPs).

Nasir Hussain, Medicines and Healthcare Products Regulatory Agency (MHRA),UK

Plenary Presentations

10 years of European paediatric regulation and formulation: any news?
Sandrine Chiappini, EMA, United Kingdom

Off patent of the radar? Scoping the needs for paediatric formulation of old medicine
Catherine Litalien, The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine, Canada
Confidential- Presentation unavailable

The birth of PaedForm: a pan-European Paediatric Formulary by EDQM
Jörg Breitkreutz, Heinrich-Heine-University Düsseldorf, Germany Dirk Leutner, Council of Europe - EDQM & HealthCare, France

3D printing: the future of patient centric manufactured medicine and clinical phase appropriate products?
Mohamed Albed Alhnan, University of Central Lancashire, United Kingdom.
Confidential- Presentation unavailable

Focus Session Presentations

Taste Assessment & Taste Masking (TATM)

TB Alliance and PepsiCo partnership: leveraging shared expertise to help eliminate unpleasant taste of TB medicines
Rajneesh Taneja, TB Alliance, United States.
Confidential- Presentation unavailable

Pharmaceutical cocrystals: recent advances, current challenges and unrealised opportunities in paediatric drug formulation
Dejan-Krešimir Bucar, University College London, United Kingdom.
Confidential- Presentation unavailable

Administration Devices

And the winner of the Open Innovation Device Challenge: System for dosing and dispensing multiparticulate formulations of pediatric drugs is...
Jeremy A. Bartlett, Pfizer, United States

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington, Merck & Co., Inc., United States

Age Approriateness of Formulations

The Global Accelerator for Paediatric Formulations (GAP-f) Ensuring children have accelerated access to optimal drug formulations
Sébastien Morin (IAS)

Accelerated Development of a Chlorhexidine Gel for the Prevention of Omphalitis in Newborns
Lee Immins, GlaxoSmithKline, United Kingdom. Trevor Riley, GlaxoSmithKline, United Kingdom

Excipients

Safety assessment of excipients –an industry view
Jim Ridings, GlaxoSmithKline, United Kingdom

The Use of colours in medicines
Gary Inwards, MHRA, United Kingdom

Biopharmaceutics

The gastrointestinal environment in paediatrics: what do we (not) know?
Jens Van Den Abeele, University of Leuven, Belgium

Biopharmaceutics evaluation of solid dispersion-based paediatric dosage forms – The new frontier
Henry Yunhui Wu, Merck, United States

Japan showcase

International chapter on paediatric formulations Initiatives for pediatric medicine development in Toyama Prefecture, Japan’s top pharmaceutical production base - Unique collaboration between regional government, academia and industries
ment, academia and industries Tomonori Shiokawa, Toyama Prefectural Government of Japan, Japan Hidemasa Nagai, Toyama Prefectural Institute for Pharmaceutical Research of Japan, Japan

Innovation Showcase Presentations

ODF (Oral Disintegrating Film) as a delivery system for (case studies)
Carmen Popescu, Roquette America Inc, Switzerland
Confidential- Presentation unavailable

“Dial the Dose” – a precision liquid dispenser
Corinna Fischer, Balda Medical GmbH & Co. KG, Germany

Case Studies

Acceptability and palatability studies in PIPs and MAA
Nasir Hussain, MHRA, United Kingdom

Infacort®: A PUMA application success story
Martin Whitaker, The University of Sheffield, United Kingdom
Confidential- Presentation unavailable

Poster Presentations

Development of a suspension vehicle for pediatric extemporaneous preparations
Hugo Alarie. Faculty of Pharmacy, University of Montreal, Montréal, Québec, Canada

Case report of a skin viral infection treated with a topical extemporaneous preparation
Maria Carvalho. PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA, Prescription Shoppe, 15247 Eleventh Street, Victorville, CA 92395, USA

Addressing Challenges in Pediatric Formulation Development toImprove Compliance and Therapeutic Outcomes
Graeme Macleod. SPI Pharma, 13240 Septemes-Les Vallons, France, SPI Pharma, 503 Carr Rd, Wilmington Delaware, USA 19809

Tribology as an assessment tool for texture evaluation of pharmaceutical coatings
J.K. Czarnocka. School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK, School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, UK

Efficient taste masking through high shear coating with lipid excipients
Rosiaux, Y. D Gatttefossé SAS, 36 chemin de Genas, 69804 Saint-Priest, France,

Minitablets with benzodiazepines as a potential new dosage form in paediatrics
Hanna Kotlowska. Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera St., 80-416 Gdansk, Poland, Student Chapter of the International Society for Pharmaceutical Engineering, Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland

Applying orodispersible tablets technology "HOWATT" to minitablets
Takao Shimatani. Teika Pharmaceutical Co., Ltd., 3-27, Arakawa, 1-chome, Toyama-shi, Toyama, Japan

Development of a Chlorhexidine Digluconate Gel 7.1% w/w Product for the Prevention of Omphalitis in Developing Countries
Lee Immins. GlaxoSmithKline R&D Ltd, David Jack Centre for R&D, Park Road, Ware, Herts, SG12 0DP, United Kingdom

Oral gels for extemporaneous paediatric formulations – stability of candesartan cilexetil preparations
Monika Trofimiuk. Medical University of Bialystok, Faculty of Pharmacy, Bialystok, Poland, Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy, Gdansk, Poland

3D printed hydrocortisone tablets: a solution for accurate dosing in children
Mohamed A Alhnan. MB025 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK, NIHR Alder Hey Clinical Research Facility for Experimental Medicine, Liverpool, UK

Child-driven design of milk micelles for drug delivery
Tânia Fernandes. CiiEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto 1649-003 Lisboa, Portugal

Delayed release orodispersible mini-tablets
Anna Kira Adam. Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-university Duesseldorf

What makes orodispersible films patient-centric dosage form? Identifying critical acceptability attributes
Mariagiovanna Scarpa. UCL School of Pharmacy, Department of Pharmaceutics, 29-39 Brunswick Square WC1N 1AX, London - UK RCPE GmbH, Inffeldgasse 13, 8010 Graz - AT

Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing
M.Peak Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP

A feasibility study to assess the acceptability of solid dosage forms in children
P.Mistry, Paediatric Medicines Research Unit, Alder Hey Children’s NHS Foundation Trust, Liverpool, L12 2AP

Compounded medicines most in need of commercialized oral pediatric formulations: a Pan-Canadian study
C. Litalien. The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Ste-Justine (The Goodman Centre), 3175 Côte-Ste-Catherine, H3T1C5, Montréal, Canada

Development of Taste-masked Dexibuprofen Orally Disintegrating Film for Children
Song Chan-Woo. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners?
C. Watson. School of Pharmacy, Institute of Clinical Sciences, The University of Birmingham, Edgbaston, B15 2TT, UK

Realizing individualized minitablet administration through efficient dosing spoon design and development
Andrew Farrington. Merck & Co., Inc., West Point, PA, USA

Gender differences and acceptability of children’s oral antibiotics
Elin Høien Bergene. Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim

Taste Masking using Lipids in the Preparation of Syrup Formulation of Lipophilic Drugs
Song Sang-Byeong. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Design of Experiments to Optimize Hollow Microneedle Arrays Fabricated by 3D Printing
Song Sang-Byeong. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

3D printed 2-layered dissolving type microneedles prepared with photo-polymer and Kollidon VA 64/ Kollidon 90 F ethanol solution
Jung Ki-Won. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea

Physical and chemical stability of phenobarbital 1mg/mL and 50 mg/mL oral suspensions (SuspendIt™)
Daniel Banov. PCCA, 9901 South Wilcrest Drive, Houston, TX 77099, USA

Influence of user and medicine characteristics on acceptability in paediatric
Thibault VALLET. ClinSearch, Malakoff, France & Laboratoire Conception de Produits et Innovation (LCPI), Arts et Métiers ParisTech, Paris, France

Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue, invitro release analysis and Human Taste Panel Assessments
S.Keser Glatt GmbH, D-79589 Binzen

Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated β-cyclodextrins
I. Speer. Sapiotec GmbH, Zeller Str. 3, 97083 Würzburg, Germany

ODF (Oral Disintegrating Film) as a pediatric centric delivery system
Carmen Popescu, Roquette America Inc

Development of 3D Printable Extrudates Containing Levetiracetam for Paediatrics
I. El Aita. Heinrich Heine University Duesseldorf, Germany

Adaptability of orally-disintegrating mini-tablet for pediatric dosage form
Makoto Shuto. Faculty of Pharmaceutical Science, Setsunan University, 45-1, Ngaotoge-cho, Hirakata, Osaka, Japan

Innovative age-adapted formulation for treatment of dRTA with a 12-hour coverage
Caroline Roussel-Maupetit. Advicenne, France

Approaches for the In Vitro Evaluation of Taste-Masking in PaediatricFormulations
Sharareh Salar-Behzadi. RCPE GmbH, Graz, Austria, 2 University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Off-label use of IV sildenafil: compatibility with other commonly administered medications in paediatric critical care
Alsalman, F. School of Pharmacy, Royal College of Surgeons in Ireland, Dublin

Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices
Erik Wollmer. Ernst-Moritz-Arndt University Greifswald, Department of Pharmacy, Felix-Hausdorff Straße 3, C_DAT, 17489 Greifswald, Germany

Assessment of excipient administration in relation to dosages in a paediatric hospital
A.C. van der Vossen. Department of Hospital Pharmacy

Composite – Drug Dosage Forms Made from Tablet and Film Formulations
D. Kottke. Heinrich-Heine-Universität Düsseldorf

Analysing Novel Nipple Shield Drug Delivery System with CFD Simulations
William H. Marks. Department of Medicine, University of Cambridge, Cambridge, UK

Preclinical Evaluation of Two Age-Appropriate Oral Formulations for Co-administration in Pediatric Subjects
Wei Zhu. Pharmaceutical Sciences and Clinical Supply

Assessing the sample size necessary for a human taste panel
Alexander Keeley. UCL. 29-39 Brunswick Square, London, WC1N 1AX;

A spoonful of sugar does not always help the medicine go down – Assessing co-administration of medicine with liquid foodstuffs
Robert Ives. Comparative and Translational Sciences, GSK Stevenage

Are Rats Supertasters?
Alexander Keeley. UCL. 29-39 Brunswick Square, London, WC1N 1AX; 2 Supervisor; 29-39 Brunswick Square, London

Taste assessment of electrospun chlorpheniramine maleate fibres using an electronic taste sensing system
Hend Abdelhakim. School of Pharmacy, University College London, UK

Three poster award winners:

  • Cameron Watson- Abstract ID: 24 (Manipulation of hydrocortisone tablets: Do parents follow the advice from healthcare practitioners)
  • Isabell Speer- Abstract ID: 40 (Enhanced oromucosal permeation of midazolam hydrochloride released from mucoadhesive buccal films using methylated Beta cyclodextrins)
  • Erik Wollmer- Abstract ID: 48 (Dissolution and compatibility of hydrocortisone granules following exposure to common paediatric administration fluids and food matrices)
  • Oral presentation award winner:

  • Bastian Hahn- Abstract ID: 50 (Extrusion of highly drug loaded wax extrudates for pediatric use
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